Postnatal changes in thiol: protein-disulfide oxidoreductase immunoreactivity of rat brain

Thiol: Protein-disulfide oxidoreductase (TPO) was localized in the brain of juvenile and adult rats by use of the unlabeled immunoperoxidase technique. In the brain of adult animals, TPO protein was revealed in neurons of Nucc. supraopticus and paraventricularis as well as in the subcommissural organ. In the developing rat, TPO seems to be a constituent of almost all neurons. The roles played by the enzyme remain to be elucidated, however.