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Aprepitant for gefitinib-induced refractory pruritus in Chinese malignancy population
Haifeng Qin1, Fang Wang1, Ke Wang2
1Department of Pulmonary Neoplasm Internal Medicine, 307 Hospital of PLA, Beijing 100000, China.
Abstract:
Targeted therapy is an important anti-cancer therapy in non-small cell lung cancer (NSCLC). Pruritus are the common side-effect with gefitinib, an anti-EGFR antibody and tyrosine-kinase inhibitor. We reported case reports to confirm the effects of aprepitant, a neurokinin receptor to management of refractory rash and pruritus in Chinese malignancy population. patients showed a rapid recovery from refractory pruritus, no adverse events occurred. Weekly follow-up visits showed the pruritus were stable and no further episodes was recorded.
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