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Updated: Jan 27, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

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Thrombin generation is increased in patients with Clostridium difficile colitis - a pilot study

Romeo G Mihăilă1,2, Crina Cătană3, Ariela L Olteanu4

  • 1a Faculty of Medicine , "Lucian Blaga" University of Sibiu , Sibiu , Romania.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|March 26, 2019
PubMed

Insights

Clostridium difficile (CD) colitis patients show increased thrombin generation, indicating a higher risk of blood clots. This finding suggests a need for monitoring and potential thromboprophylaxis in these individuals.

Area of Science:

  • Coagulation and Thrombosis
  • Infectious Diseases
  • Gastroenterology

Background:

  • Limited data exists on thrombotic risk in Clostridium difficile (CD) colitis.
  • CD colitis is a globally prevalent condition.
  • Evaluating coagulation is crucial for understanding patient risk.

Purpose of the Study:

  • To investigate thrombin generation in patients with CD colitis.
  • To assess the coagulation status in CD colitis patients.
  • To identify potential thrombotic risks associated with CD colitis.

Main Methods:

  • Prospective observational study over 15 months.
  • Inclusion of hospitalized patients diagnosed with CD colitis.
  • Thrombin generation analysis using a Ceveron® alpha analyzer in platelet-poor plasma.
  • Comparison with healthy volunteer control subjects.

Main Results:

  • Thirty-three CD colitis patients and 51 controls were analyzed.
  • Significantly higher mean velocity index and peak thrombin levels observed in patients compared to controls (p=0.010, p=0.0395).
  • Thrombin generation patterns suggest potential thrombotic risk in CD colitis patients without septic shock.
  • Mean velocity index correlated with Charlson age-comorbidity index for estimated mortality risk.

Conclusions:

  • Elevated thrombin generation in CD colitis patients suggests an increased thromboembolic risk.
  • Thrombin generation patterns can identify patients at higher risk.
  • These patients may benefit from thromboprophylaxis strategies and closer monitoring.

Keywords:
coagulationcolitisthrombin generationthrombotic risk

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