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Related Experiment Videos

Fever: is it beneficial?

C M Blatteis

    The Yale Journal of Biology and Medicine
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Fever may aid lizard survival, but its benefits in mammals are unclear. Current evidence does not conclusively prove fever enhances survival in mammals during infection.

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    Area of Science:

    • Immunology
    • Physiology
    • Evolutionary Biology

    Background:

    • Fever is a common response to infection, with potential adaptive benefits suggested by studies in ectotherms like lizards.
    • In mammals, the adaptive value of fever is debated, with conflicting evidence regarding its impact on survival.
    • In vitro studies show enhanced leukocyte function at higher temperatures, proposing a mechanism for fever's benefits.

    Purpose of the Study:

    • To evaluate the conclusive evidence for the survival value of fever in mammals.
    • To address the extrapolation of findings from ectotherms and in vitro experiments to in vivo mammalian conditions.

    Main Methods:

    • Review of existing studies on fever and infection in mammals.
    • Analysis of data from ectotherm studies and in vitro experiments.

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  • Consideration of clinical observations regarding antipyretic use.

    • Main Results:

    • Evidence for fever's survival benefit in mammals remains equivocal and inconsistent.
    • Extrapolation of ectotherm and in vitro findings to mammalian in vivo conditions is questionable.
    • Widespread use of antipyretics without apparent negative consequences suggests limited essential benefit of fever.

    Conclusions:

    • Conclusive evidence supporting a significant survival advantage of fever in mammals is currently lacking.
    • Fever's role in mammalian infection response requires further investigation beyond in vitro and ectotherm models.
    • The cardinal manifestation of fever in infection does not automatically equate to a critical survival benefit in mammals.