Free-breathing quantification of regional ventilation derived by phase-resolved functional lung (PREFUL) MRI

To test the feasibility of regional fully quantitative ventilation measurement in free breathing derived by phase-resolved functional lung (PREFUL) MRI in the supine and prone positions. In addition, the influence of T₂ * relaxation time on ventilation quantification is assessed.

Twelve healthy volunteers underwent functional MRI at 1.5 T using a 2D triple-echo spoiled gradient echo sequence allowing for quantitative measurement of T₂ * relaxation time. Minute ventilation (ΔV) was quantified by conventional fractional ventilation (FV) and the newly introduced regional ventilation (VR), which corrects volume errors due to image registration. ΔV_FV versus ΔV_VR and ΔV_VR versus ΔV_VR with T₂ * correction were compared using Bland-Altman plots and correlation analysis. The repeatability and physiological plausibility of all measurements were tested in the supine and prone positions.

On global and regional scales a strong correlation was observed between ΔV_FV versus ΔV_VR and ΔV_VR versus ΔV_VRT2* (r > 0.93); however, regional Bland-Altman analysis showed systematic differences (p < 0.0001). Unlike ΔV_VRT2* , ΔV_VR and ΔV_FV showed expected physiologic anterior-posterior gradients, which decreased in the supine but not in the prone position at second measurement during 3 min in the same position. For all quantification methods a moderate repeatability (coefficient of variation <20%) of ventilation was found.

A fully quantified regional ventilation measurement using ΔV_VR in free breathing is feasible and shows physiologically plausible results. In contrast to conventional ΔV_FV, volume errors due to image registration are eliminated with the ΔV_VR approach. However, correction for the T₂ * effect remains challenging.