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Asymmetric Lewis Acid Catalyzed Electrochemical Alkylation
Qinglin Zhang1, Xihao Chang1, Lingzi Peng1
1Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, China.
Abstract:
Lewis-acid catalysis and electrochemistry represent two powerful fields that have found widespread application in organic chemistry. Reported herein is an asymmetric electrosynthesis in combination with a chiral Ni catalyst leading to an intermolecular alkylation reaction in good yields with excellent enantioselectivities (up to 97 % ee). Mechanistic studies suggest that the Lewis-acid-bound radical intermediate from a single-electron anodic oxidation selectively reacts with the benzylic radical species to generate the desired adducts.
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