Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extracellular Matrix01:42

The Extracellular Matrix

88.6K
Overview
88.6K
The Extracellular Matrix01:29

The Extracellular Matrix

12.1K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.1K
Extracellular Matrix01:26

Extracellular Matrix

5.3K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.3K
The Bone Matrix01:18

The Bone Matrix

5.6K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.6K
Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

5.0K
Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
5.0K
Golgi Matrix Proteins01:12

Golgi Matrix Proteins

2.4K
Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decoding the dynamic extracellular matrix in cancer-3D models and bioscaffolds rewire the rules of tumor progression.

FEBS letters·2026
Same author

Extracellular matrix cross-talk with proteases: A master switch for remodeling and cell regulation in health and disease.

The FEBS journal·2026
Same author

Serglycin Across the Disease Spectrum: A Multifunctional Proteoglycan in Inflammation and Cancer.

Current issues in molecular biology·2026
Same author

Serglycin Cooperates with the Unfolded Protein Response Pathway and Inflammation to Drive Glioblastoma Cell Survival.

Cells·2026
Same author

Comparative efficacy of open endarterectomy versus endovascular treatments in common femoral artery stenocclusive disease: A Bayesian hierarchical meta-analysis.

Vascular·2026
Same author

Spheroid-Based 3D Models to Decode Cell Function and Matrix Effectors in Breast Cancer.

Cancers·2025

Related Experiment Video

Updated: Jan 27, 2026

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix
08:46

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Published on: August 14, 2016

13.9K

The extracellular matrix as a multitasking player in disease.

Achilleas D Theocharis1, Dimitra Manou1, Nikos K Karamanos1

  • 1Biochemistry, Biochemical Analysis & Matrix Pathobiochemistry Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece.

The FEBS Journal
|March 26, 2019
PubMed
Summary

Extracellular matrices (ECMs) are dynamic tissue scaffolds. Abnormal ECM remodeling drives disease progression, highlighting the need for research into novel diagnostic and therapeutic targets for matrix-related diseases.

Keywords:
cancercollagensextracellular matrixfibrosisgenetic disordershyaluronanmatrix metalloproteinasesosteoarthritisproteoglycans

More Related Videos

Author Spotlight: Optimizing Bovine Lung Decellularization for Organotypic Hydrogels
06:12

Author Spotlight: Optimizing Bovine Lung Decellularization for Organotypic Hydrogels

Published on: December 8, 2023

2.3K
IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix
10:48

IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix

Published on: November 13, 2023

1.6K

Related Experiment Videos

Last Updated: Jan 27, 2026

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix
08:46

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Published on: August 14, 2016

13.9K
Author Spotlight: Optimizing Bovine Lung Decellularization for Organotypic Hydrogels
06:12

Author Spotlight: Optimizing Bovine Lung Decellularization for Organotypic Hydrogels

Published on: December 8, 2023

2.3K
IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix
10:48

IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix

Published on: November 13, 2023

1.6K

Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Tissue Engineering

Background:

  • Extracellular matrices (ECMs) are complex 3D scaffolds essential for tissue structure and function.
  • ECMs comprise fibrillar (collagens, fibronectin, elastin) and non-fibrillar (proteoglycans, hyaluronan, glycoproteins) molecules.
  • ECMs dynamically interact with cells, regulating phenotype and homeostasis, with composition varying across tissues and disease states.

Purpose of the Study:

  • To review critical and emerging issues in tissue matrix assembly.
  • To explore the multifaceted roles of ECM in diseases like osteoarthritis, fibrosis, cancer, and genetic disorders.
  • To discuss the mechanisms underlying matrix-based diseases.

Main Methods:

  • Literature review of current research on ECM assembly and function.
  • Analysis of ECM's role in normal tissue repair and pathological conditions.
  • Discussion of genetic mutations affecting matrix molecules.

Main Results:

  • Abnormal ECM remodeling is a key driver of disease progression through altered cell-matrix interactions.
  • Mutations in ECM genes can lead to diverse genetic disorders.
  • ECM's structure and composition are significantly altered in various diseases.

Conclusions:

  • Understanding dynamic ECM networks is crucial for identifying disease-causing abnormalities.
  • Further research into ECM can lead to novel diagnostic tools and therapeutic strategies for matrix-related diseases.
  • Targeting ECM offers potential for treating conditions such as osteoarthritis, fibrosis, and cancer.