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Published on: April 4, 2014
Redox-Neutral Decarbonylative Cross-Couplings Coming of Age
Qun Zhao1, Michal Szostak2,1
1Department of Chemistry, Rutgers University, 73 Warren Street, Newark, NJ, 07102, USA.
Abstract:
Major progress has recently been made in the challenging redox-neutral decarbonylative cross-coupling of carboxylic acids. For example, the use of acid fluorides as effective cross-coupling partners has been found to enable control of the decarbonylation selectivity and facilitates challenging Pd0 -catalyzed nucleophilic trifluoromethylation and exogenous base-free Suzuki cross-coupling reactions. In another recent advance, the use of acid chlorides in room temperature difluoromethylation and direct decarbonylative cross-coupling of carboxylic acids allows these classical substrates to be used as aryl electrophiles in cross-coupling reactions. Further challenges that are yet to be addressed in redox-neutral decarbonylative cross-couplings are also briefly summarized.
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