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Published on: June 20, 2014
Mechanochemical Rhodium(I)-Catalyzed C-H Functionalization of Indoles via Decarbonylative N-C(O) Bond Activation of
Jin Zhang1, Qianru Ma1, Renjie Li1
1College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Abstract:
Direct decarbonylative N-C(O)/C-H activation of amides with indoles has been achieved under Rh(I)-catalyzed mechanochemical conditions. The method exhibits a broad substrate scope, furnishing a diverse array of valuable 2-arylindoles by exploiting ubiquitous amide bonds in high yields and providing an entryway for late-stage functionalization of pharmaceuticals containing amides. Crucially, mechanochemical conditions operate at 90 °C in the absence of solvents, bases, and additives, permitting a substantially lower temperature for decarbonylative N-C(O) activation by a sustainable approach.
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