Adverse effects of immunoglobulin therapy

Area of Science:

• Immunology
• Pharmacology

Background:

• Immunoglobulin products contain IgG antibodies derived from healthy donor plasma.
• These products are used for substitution or immunomodulation via intravenous or subcutaneous routes.

Purpose of the Study:

• To summarize the risks and characteristics of adverse events associated with immunoglobulin administration.

Main Methods:

• Review of literature on immunoglobulin therapy and associated adverse events.
• Analysis of factors influencing adverse event occurrence and severity.

Main Results:

• Common adverse events include pyretic reactions, chills, headache, nausea, malaise, and muscle pain.
• Severe systemic reactions can also occur.
• Approximately one-third of reactions manifest during the initial administration.

Conclusions:

• Adverse event incidence and severity are influenced by dose, administration speed, route, patient comorbidities, and acute infection status.
• Therapeutic management of side effects is primarily symptomatic.