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Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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Direct Procurement of Donor Heart With Normothermic Regional Perfusion of Abdominal Organs

Prashant N Mohite1, Diana García Sáez1, Andrew J Butler2

  • 1Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield, United Kingdom.

The Annals of Thoracic Surgery
|March 27, 2019
PubMed

Insights

Direct heart procurement combined with normothermic regional perfusion for abdominal organs in circulatory death donors is feasible. This approach yielded excellent short-term outcomes for all transplanted organs and recipients.

Area of Science:

  • Cardiovascular Surgery
  • Organ Transplantation
  • Donor Management

Background:

  • Evaluating novel organ procurement strategies is crucial for expanding the donor pool.
  • Donors after circulatory death (DCD) present unique challenges for organ retrieval.
  • Normothermic regional perfusion (NRP) is an emerging technique for preserving abdominal organs.

Observation:

  • A DCD pathway was utilized for a 41-year-old female donor following an irreversible brain injury.
  • The heart was procured and reanimated using an ex situ perfusion system.
  • Simultaneously, abdominal organs underwent normothermic regional perfusion.

Findings:

  • The study successfully demonstrated the combined application of direct heart procurement and NRP for abdominal organs in a DCD donor.
  • All procured organs, including the heart and abdominal organs, showed excellent short-term outcomes post-transplantation.
  • Recipient outcomes were also favorable in the short term.

Implications:

  • This combined technique offers a potential strategy to enhance organ utilization from DCD donors.
  • Successful heart procurement alongside abdominal organ perfusion may increase the availability of vital organs for transplantation.
  • Further research is warranted to assess the long-term efficacy and broader applicability of this dual procurement method.
Abstract

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