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Updated: Jan 27, 2026

Light-Controlled Fermentations for Microbial Chemical and Protein Production
Published on: March 22, 2022
Temperature control of fermentation bioreactor for ethanol production using IMC-PID controller.
Munna Kumar1, Durga Prasad1, Balendu Shekher Giri1
1Chemical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India.
A novel Internal Model Control based Proportional Integral Derivative (IMC-PID) controller effectively regulates bioreactor temperature. This advanced control method demonstrates superior performance compared to existing techniques for unstable systems.
Area of Science:
- Chemical Engineering
- Control Systems Engineering
- Process Control
Background:
- Accurate modeling is crucial for effective process control.
- Bioreactor temperature control presents challenges due to system dynamics.
- Existing control methods may not be optimal for unstable time-delay systems.
Purpose of the Study:
- To develop and validate an IMC-PID controller for an unstable second-order time-delay (USOPDT) system with a right-half plane zero.
- To apply the developed controller to a nonlinear bioreactor process model for temperature control.
- To evaluate the controller's performance against established metrics and compare it with other methods.
Main Methods:
- State-space model identification using MATLAB yielded a 99% data fit.
- Conversion of the state-space model to a simplified unstable second-order time-delay transfer function.
- Design of an IMC-PID controller specifically for the identified USOPDT model.
- Implementation and testing of the controller on a nonlinear bioreactor model.
Main Results:
- The IMC-PID controller successfully controlled bioreactor temperature during setpoint and disturbance changes.
- Performance metrics (IAE, ISE, ITAE) were recorded as 20.99, 49.02, and 292.50, respectively.
- The proposed controller demonstrated improved closed-loop performance, particularly in Integral Absolute Error (IAE) and settling time, compared to reported methods.
Conclusions:
- The proposed IMC-PID controller is effective for temperature control of nonlinear bioreactors with USOPDT characteristics.
- The controller offers enhanced performance over existing methods for this specific class of unstable systems.
- Accurate system modeling is a critical precursor to successful advanced controller design and implementation.
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