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Psammomatoid Calcification-Rich Oncocytic Thyroid Adenoma With Clear-Cell Change
Adriana Handra-Luca1,2, Genevieve Belleannee3, Beate Straub4
1Service d'Anatomie pathologique, APHP GHU Avicenne, Universite Paris Nord Sorbonne Cite, Bobigny, France.
Clinical Pathology (Thousand Oaks, Ventura County, Calif.)
|March 27, 2019
Summary
This study details a rare oncocytic thyroid adenoma (OTA) case featuring extensive calcifications and clear-cell changes. These findings highlight unique cellular characteristics and potential markers for further investigation in thyroid pathology.
Area of Science:
- Endocrinology
- Pathology
- Oncology
Background:
- Oncocytic thyroid adenoma (OTA) can exhibit calcifications and clear-cell changes.
- These features are not always prominent or well-characterized.
Purpose of the Study:
- To report the distinctive features of an oncocytic thyroid adenoma (OTA) with extensive calcifications and a clear-cell component.
- To investigate the cellular markers associated with these unique pathological findings.
Main Methods:
- Case study of a right thyroid lobectomy specimen.
- Histopathological examination including immunohistochemistry for various markers (TTF1, S100, Bcl2, CD10, CD138, CD56, adipophilin, TIP47).
- Quantification of clear-cell change and description of calcification patterns.
Main Results:
- The oncocytic thyroid adenoma (OTA) showed 15%-20% clear-cell change.
- Numerous psammomatoid calcifications, leading to macrocalcifications, were observed.
- Nodule cells expressed TTF1, S100, Bcl2, CD10, CD138, CD56, adipophilin, and TIP47 heterogeneously.
Conclusions:
- A rare oncocytic thyroid adenoma (OTA) variant with significant calcifications and clear-cell change is presented.
- Heterogeneous expression of CD56, CD138, Bcl2, and TIP47 may be linked to calcification and clear-cell changes.
- Further research is needed to elucidate the role of these markers in OTA pathogenesis.
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