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Lipidomics Approaches: Applied to the Study of Pathogenesis in Candida Species

Ashutosh Singh1, Nitesh Kumar Khandelwal2,3, Rajendra Prasad4,5

  • 1Department of Biochemistry, University of Lucknow, Lucknow, 226007, Uttar Pradesh, India.

Progress in Molecular and Subcellular Biology
|March 27, 2019
PubMed

Insights

Fungal infections are a growing concern, especially for immunocompromised individuals. Targeting fungal lipids, like sphingolipids (SPHs), offers a promising strategy to overcome drug resistance and develop new treatments.

Area of Science:

  • Mycology
  • Biochemistry
  • Drug Discovery

Background:

  • Fungal infections pose a significant threat, particularly to immunocompromised individuals.
  • Limited effective treatments and increasing multidrug resistance necessitate novel therapeutic strategies.
  • Lipid homeostasis, especially sphingolipids (SPHs), plays a crucial role in fungal physiology and drug susceptibility.

Purpose of the Study:

  • To explore the role of lipids, particularly sphingolipids (SPHs), in the physiology and drug resistance of Candida species.
  • To highlight lipids as potential drug targets for combating fungal infections.
  • To review recent advancements in analytical tools for studying fungal lipidomics.

Main Methods:

  • Literature review focusing on lipid metabolism and drug resistance in fungal pathogens.
  • Analysis of the role of sphingolipids (SPHs) and other lipids in Candida albicans virulence and signaling.
  • Discussion of high-throughput analytical techniques for lipid structure and biosynthesis elucidation.

Main Results:

  • Lipid imbalances, especially in sphingolipids (SPHs), significantly influence the drug susceptibility of Candida cells.
  • Sphingolipids (SPHs) and their intermediates are critical regulators of cell signaling and virulence in C. albicans.
  • Understanding fungal lipidomics is key to identifying novel therapeutic targets.

Conclusions:

  • Lipids, particularly sphingolipids (SPHs), are vital targets for developing new antifungal drugs.
  • Investigating fungal lipid homeostasis provides insights into overcoming multidrug resistance.
  • Advanced analytical methodologies are crucial for advancing our understanding of fungal lipid roles.
Keywords:
FunctionsLipidsMass spectrometryPathogenic fungi

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