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Regulation of signaling pathways by β-elemene in cancer progression and metastasis

Muhammad Z Qureshi1, Rukset Attar2, Mirna A Romero3

  • 1Department of Chemistry, GCU, Lahore, Pakistan.

Journal of Cellular Biochemistry
|March 27, 2019
PubMed

Insights

Beta-elemene shows promise in cancer treatment by modulating key cell signaling pathways. Clinical trial results are being analyzed to identify patients who will benefit most from this compound.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Beta-elemene is a compound derived from traditional Chinese medicine.
  • It has demonstrated anticancer properties in preclinical studies.
  • Its entry into clinical trials highlights its therapeutic potential.

Purpose of the Study:

  • To review the mechanisms by which beta-elemene modulates cancer cell signaling pathways.
  • To summarize the regulation of specific pathways including TNF-related apoptosis-inducing ligand, STAT, TGF/SMAD, NOTCH, and mTOR by beta-elemene.
  • To discuss clinical trial outcomes and patient stratification strategies for beta-elemene therapy.

Main Methods:

  • Literature review of preclinical and clinical studies on beta-elemene.
  • Analysis of data on beta-elemene's effects on various cancer cell signaling pathways.
  • Synthesis of information regarding clinical trial results and patient selection criteria.

Main Results:

  • Beta-elemene effectively modulates multiple cancer-related signaling pathways.
  • Specific pathways regulated include TNF-related apoptosis-inducing ligand, STAT, TGF/SMAD, NOTCH, and mTOR.
  • Clinical trial data are emerging, indicating therapeutic potential.

Conclusions:

  • Beta-elemene is a significant candidate for mainstream cancer therapy.
  • Understanding its pathway modulation is key to its effective clinical application.
  • Patient stratification based on clinical trial data will optimize treatment outcomes.
Keywords:
apoptosiscancerelemenesignaling

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