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JNK signaling in cancer cell survival

Qinghua Wu1,2,3, Wenda Wu2,3, Bishi Fu4

  • 1College of Life Science, Yangtze University, Jingzhou, China.

Medicinal Research Reviews
|March 27, 2019
PubMed

Insights

The Janus kinase (JNK) signaling pathway, once linked to cancer cell death, now shows a dual role promoting cancer cell survival and chemoresistance. Understanding JNK

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cell Signaling

Background:

  • c-Jun N-terminal kinase (JNK) signaling is implicated in cancer cell apoptosis.
  • Emerging evidence reveals JNK's pro-survival role, often acting with other pathways like NF-κB and JAK/STAT.
  • JNK influences autophagy, impacting cancer cell survival and therapeutic resistance.

Purpose of the Study:

  • To review recent advancements in understanding JNK's pro-survival functions in cancer.
  • To analyze the molecular mechanisms behind JNK-mediated cancer cell survival.
  • To explore the distinct roles of JNK1 and JNK2 in cancer cell survival and therapeutic potential.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of molecular mechanisms of JNK signaling in cancer.
  • Focus on JNK's interaction with other signaling pathways and cellular processes.

Main Results:

  • JNK promotes cancer cell survival by regulating autophagy and interacting with pathways like NF-κB and JAK/STAT.
  • JNK's prosurvival effects are linked to immune evasion mechanisms and compensatory cell proliferation.
  • JNK signaling contributes to chemotherapeutic resistance.
  • Distinct roles of JNK1 and JNK2 in regulating cancer cell survival are highlighted.

Conclusions:

  • JNK signaling plays a critical, albeit complex, role in promoting cancer cell survival and chemoresistance.
  • Understanding the nuanced functions of JNK, including JNK1 and JNK2, offers potential therapeutic strategies for cancer treatment.
  • Targeting JNK pathways may overcome chemoresistance and enhance anti-cancer therapies.
Keywords:
JNKc-Jun N-terminal kinasecancercell survivalchemoresistancetumor development

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