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Clinical Significance of HBOT in Hypoxia-Induced Pathophysiological Conditions: A Comprehensive Investigative Study
Rashi Bhargava1, Kanchan Bhardwaj1, Patrik Oleksak2
1School of Basic and Applied Sciences, Shri Guru Ram Rai University, Dehradun, 248001, India.
Current Medicinal Chemistry
|April 13, 2026
Summary
Hyperbaric oxygen therapy (HBOT) enhances tissue oxygenation and shows promise for neurological and non-neurological conditions. Evidence-based protocols guide its use in various disorders, improving patient outcomes.
Area of Science:
- Hyperbaric Medicine
- Physiology
- Neuroscience
Background:
- Hyperbaric oxygen therapy (HBOT) involves breathing pure oxygen at elevated pressures, increasing tissue oxygen levels.
- HBOT efficacy is dose-dependent and crucial for treating hypoxic tissues.
- It offers neuroprotection and treats conditions like Fournier's gangrene, osteomyelitis, and carbon monoxide poisoning.
Purpose of the Study:
- To review the properties and physiological relevance of HBOT.
- To explore clinical evidence, indications, and mechanisms for various disorders.
- To highlight HBOT's potential in neurological and neuropsychological conditions.
Main Methods:
- Review of clinical evidence and established protocols.
- Discussion of physiological effects of oxygen under pressure.
- Analysis of therapeutic applications and underlying mechanisms.
Main Results:
- HBOT is effective for hypoxic and ischemic tissues, including COVID-19-associated hypoxemia.
- It shows promising outcomes in neurological and neuropsychological disorders, improving neuronal activation and cognitive function.
- Clinical evidence supports HBOT's efficacy in treating both acute and chronic conditions.
Conclusions:
- HBOT is a valuable therapeutic intervention with a growing range of applications.
- Further research into HBOT mechanisms and protocols is supported by clinical evidence.
- HBOT demonstrates significant potential for enhancing recovery and treating diverse medical conditions.
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