Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extracellular Matrix01:42

The Extracellular Matrix

88.6K
Overview
88.6K
The Extracellular Matrix01:29

The Extracellular Matrix

12.1K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.1K
Protein Complex Assembly02:41

Protein Complex Assembly

16.7K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.7K
The Bone Matrix01:18

The Bone Matrix

5.6K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.6K
Extracellular Matrix01:26

Extracellular Matrix

5.3K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.3K
Spindle Assembly02:50

Spindle Assembly

4.2K
Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid phylogenomic analysis for viral surveillance and metagenomic profiling with Omni2Tree.

bioRxiv : the preprint server for biology·2026
Same author

Movi Color: fast and accurate taxonomic classification with the move structure.

ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine·2026
Same author

Minimizing reference bias with an imputed personalized reference.

Genome research·2026
Same author

Correction: Reconstructing Evolutionary Histories with Hierarchical Orthologous Groups.

Journal of molecular evolution·2025
Same author

Reconstructing Evolutionary Histories with Hierarchical Orthologous Groups.

Journal of molecular evolution·2025
Same author

OrthoXML-Tools: A Toolkit for Manipulating OrthoXML Files for Orthology Data.

Journal of molecular evolution·2025
Same journal

Invaders taking over-Mollusc faunal change in volcanic barrier lakes of the Albertine Rift biodiversity hotspot.

PloS one·2026
Same journal

AI-driven molecular diversification and ligand-based optimization of macitentan derivatives targeting VEGFR1 and endothelin signaling pathways.

PloS one·2026
Same journal

Performance patterns and records in the world aquatics masters championships: Where do the most frequently represented nations among the top-ten masters swimmers come from?

PloS one·2026
Same journal

Modeling diurnal Temperature-Rainfall relationships under multicollinearity using PLS-SEM: A case study of Ghana.

PloS one·2026
Same journal

Organizational culture, social capital, and emergency capacity in primary healthcare institutions: A cross-sectional structural equation modeling study comparing ordinary and older communities.

PloS one·2026
Same journal

Impact of kidney function on the metabolome in the general population.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Jan 27, 2026

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

1.5K

NGS based haplotype assembly using matrix completion.

Sina Majidian1, Mohammad Hossein Kahaei1

  • 1School of Electrical Engineering, Iran University of Science & Technology, Narmak, Tehran, Iran. 16846-13114.

Plos One
|March 27, 2019
PubMed
Summary
This summary is machine-generated.

New algorithms for haplotype assembly use matrix completion to reconstruct DNA sequences from next-generation sequencing (NGS) reads. HapOPT shows improved SNP missing rates and haplotype block lengths compared to existing methods.

More Related Videos

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
12:08

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Published on: August 20, 2021

5.8K
Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids
09:18

Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids

Published on: October 7, 2020

7.3K

Related Experiment Videos

Last Updated: Jan 27, 2026

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

1.5K
Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
12:08

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Published on: August 20, 2021

5.8K
Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids
09:18

Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids

Published on: October 7, 2020

7.3K

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Haplotype assembly is crucial for understanding genetic variation.
  • Existing methods face challenges with accuracy and efficiency.

Purpose of the Study:

  • To develop novel algorithms for haplotype assembly using matrix completion.
  • To evaluate the performance of these algorithms against state-of-the-art methods.

Main Methods:

  • Applied matrix completion to convert next-generation sequencing (NGS) reads into an incomplete matrix.
  • Developed HapSVT, HapNuc, and HapOPT algorithms for matrix completion, quantization, and decoding.
  • Compared proposed algorithms with existing methods using simulated and real fosmid data.

Main Results:

  • The HapOPT algorithm demonstrated superior SNP missing rates and haplotype block lengths.
  • HapOPT achieved comparable accuracy to HapCUT2 in terms of reconstruction and switch error rates.
  • The developed algorithms offer a promising approach for accurate haplotype reconstruction.

Conclusions:

  • Matrix completion provides an effective framework for haplotype assembly.
  • HapOPT represents an advancement in haplotype assembly algorithms, offering improved performance.
  • The MATLAB implementation is publicly available for research use.