One pocket, two poses: How sequence context shapes non-additive binding
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Updated: Nov 7, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
Published on: August 15, 2018
Jingyou Rao1, Willow Coyote-Maestas2
1Department of Bioengineering and Therapeutic Science, University of California, San Francisco, San Francisco, CA, USA.
Abstract:
In a recent issue, Jiang et al.1 combine combinatorial mutagenesis, reference-independent epistasis analysis, binding measurements, NMR, and molecular dynamics to show how specific peptide conformations and PIN1 residues generate non-additive recognition, directly linking statistical epistasis to concrete molecular mechanisms across a complete sequence landscape.
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