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Emerging therapeutic targets for patients with advanced prostate cancer

Fred Saad1, Neal Shore2, Tian Zhang3

  • 1Centre Hospitalier de l'Université de Montréal/CRCHUM, Montréal, Quebec, Canada.

Cancer Treatment Reviews
|March 27, 2019
PubMed

Insights

New treatments targeting cell signaling, DNA repair, and epigenetic pathways show promise for advanced castration-resistant prostate cancer (CRPC). Novel agents and vaccines are being evaluated in clinical trials for improved disease control.

Area of Science:

  • Oncology
  • Cancer Therapeutics
  • Prostate Cancer Research

Background:

  • Advanced castration-resistant prostate cancer (CRPC) remains a significant cause of morbidity and mortality.
  • Treatment resistance after multiple therapies presents a major clinical challenge.
  • Existing treatments have improved outcomes but further advancements are needed.

Purpose of the Study:

  • To review novel therapeutic targets and agents for CRPC.
  • To discuss emerging small-molecule inhibitors and prostate cancer vaccines.
  • To highlight potential new treatment strategies for advanced prostate cancer.

Main Methods:

  • Review of preclinical and clinical trial data for novel CRPC agents.
  • Discussion of targeted therapies including poly ADP-ribose polymerase (PARP) and enhancer of zeste homologue 2 (EZH2) inhibitors.
  • Overview of current prostate cancer vaccine candidates.

Main Results:

  • Several novel agents targeting key pathways are under clinical investigation.
  • Various prostate cancer vaccines are in different stages of clinical trials.
  • These strategies target known drivers of prostate cancer growth and progression.

Conclusions:

  • Novel targeted therapies and vaccines offer promising avenues for CRPC treatment.
  • Ongoing phase III trials may yield new effective combination therapies.
  • These advancements hold potential for enhanced disease control in advanced prostate cancer patients.
Keywords:
CRPCEZH2PARPTargetTyrosine kinaseVaccine

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