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Updated: Jan 27, 2026

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Differential potential ratiometric sensing platform for enantiorecognition of chiral drugs
Bin Liu1, Huiting Lian1, Lu Chen1
1College of Materials Science and Engineering, Huaqiao University, Key Laboratory of Molecular Designing and Green Conversions Fujian University, Xiamen, 361021, People's Republic of China.
Abstract:
A versatile, robust and efficient differential potential ratiometric sensing platform was developed for enantioselective recognition of dual chiral targets based on a composite membrane of molecularly imprinted polymers (MIPs) and reduced graphene oxide (rGO) modified glassy carbon electrode (GCE). The functional chitosan-based MIPs and rGO were compatibly immobilized on the GCE with high selectivity and efficient signal amplification. Moreover, via the systematic optimization of series conditions, a distinct potential difference (PD), reaching 135 mV, was obtained between the R-/S-prop based on the MIPs/rGO/GCE. In a controllable concentration range from 50 μM to 1000 μM, different ratios of R-/S-prop were linearly related to the peak potentials (Eps) in the racemic mixture. Using this low-cost reversible electrochemical platform, both Prop enantiomers were simultaneously identified with high repeatability and time-based stability. This novel semi-quantitative electrochemical sensing platform was established to rapidly quantify the ratio of S-/R-prop by Ep for the chiral drug recognition with great potential for practical applications in fields of pharmacological detection and clinical analysis.
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