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Enucleation of the Prostate for the Treatment of Benign Prostatic Hyperplasia Using a 980 nm Diode Laser
Published on: May 5, 2020
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Baseline Basal Cell Hyperplasia Is not Associated With Baseline Lower Urinary Tract Symptoms, Baseline Clinical
Dmo Freitas1, G L Andriole2, S J Freedland3
1Division of Urology, Nossa Senhora da Conceicao Hospital, Porto Alegre, RS, Brazil; Urologist at Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Urology
|March 28, 2019
Summary
Basal cell hyperplasia (BCH) in negative prostate biopsies is linked to more atrophy and less inflammation but does not predict future prostate cancer (PCa), benign prostatic hyperplasia (BPH), or prostatitis.
Area of Science:
- Urology
- Pathology
- Oncology
Background:
- Basal cell hyperplasia (BCH) is a finding in prostate biopsies.
- Its association with clinical outcomes like lower urinary tract symptoms (LUTS), benign prostatic hyperplasia (BPH), and prostate cancer (PCa) requires further investigation.
Purpose of the Study:
- To determine if basal cell hyperplasia (BCH) in initial negative prostate biopsies correlates with concurrent lower urinary tract symptoms (LUTS), benign prostatic hyperplasia (BPH), clinical prostatitis, or future prostate cancer (PCa) risk.
Main Methods:
- A retrospective analysis of 6471 men aged 50-75 with PSA 2.5-10 ng/ml and prior negative biopsy was conducted.
- Data from the Reduction by Dutasteride of PCa Events trial, including repeat biopsies, were analyzed.
- Logistic regression models assessed the association between baseline BCH and outcomes, controlling for patient characteristics.
Main Results:
- Basal cell hyperplasia (BCH) was present in 1.3% of baseline biopsies and associated with more prostate atrophy and less chronic inflammation.
- BCH was not significantly associated with future prostate cancer (PCa) risk in repeat biopsies.
- No significant association was found between BCH and benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) or clinical prostatitis.
Conclusions:
- In men with initially negative prostate biopsies, basal cell hyperplasia (BCH) is linked to histological atrophy and reduced chronic prostatitis.
- Basal cell hyperplasia (BCH) does not appear to be a reliable predictor of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS), clinical prostatitis, or future prostate cancer (PCa).
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