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Use of Catridecacog in a patient with severe Factor XIII deficiency undergoing surgery

Gianluca Sottilotta1, Francesca Luise1, Vincenzo Oriana1

  • 1UOSD Microcitemie - Centro Emofilia - Servizio Emostasi e Trombosi, Grande Ospedale Metropolitano Bianchi- Melacrino-Morelli, Reggio Calabria.

Hematology Reports
|March 28, 2019
PubMed

Despite many articles regarding the antihemorrhagic treatment and prophylaxis, there is a lack of experience about how to best conduct major surgical procedures in patients with congenital factor XIII (FXIII) deficiency. Here we report a case of surgery (right inguinal hernia, complicated by heaviness and pain) performed in a patient with FXIII deficiency, receiving recombinant FXIII prophylaxis (Catridecacog 35 UI/kg every 28±2 days). Our experience shows that Catridecacog can be used safely and effectively not only for continued prophylaxis but also in surgery and adds to the very limited body of evidence currently available on surgery in this bleeding disorder.

Keywords:
Recombinant FXIIIcongenital FXIII deficiencysurgery

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