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Related Experiment Video

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Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
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Th9 Cells in Allergic Disease.

Pornpimon Angkasekwinai1

  • 1Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, 12120, Thailand. upornpim@tu.ac.th.

Current Allergy and Asthma Reports
|March 28, 2019
PubMed
Summary

This review details the role of Th9 cells, a novel T helper subset producing IL-9, in allergic diseases. It highlights their involvement in conditions like asthma and atopic dermatitis, and discusses epigenetic regulation.

Area of Science:

  • Immunology
  • Allergy Research

Background:

  • Th9 cells are a newly identified subset of effector T helper cells.
  • These cells are characterized by their primary production of Interleukin-9 (IL-9).

Purpose of the Study:

  • To provide an updated overview of Th9 cell functions in allergic inflammatory diseases.
  • To synthesize recent findings on Th9 cells' contribution to various allergic conditions.

Main Methods:

  • Literature review of recent scientific reports and studies.
  • Analysis of data concerning IL-9 production and Th9 cell involvement.

Main Results:

  • Th9 cells play a significant role in the pathogenesis of allergic rhinitis, asthma, atopic dermatitis, contact dermatitis, and food allergy.
Keywords:
Allergic diseasesAllergyAsthmaIL-9T helper cellTh9

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  • Multiple sources of IL-9 exist beyond Th9 cells, contributing to allergic inflammation.
  • Epigenetic factors regulating IL-9 production by Th9 cells are emerging as therapeutic targets.

    • Conclusions:

    • Th9 cells are crucial players in diverse allergic diseases affecting airways, skin, and the gastrointestinal tract.
    • Understanding Th9 cell function and regulation is vital for developing new allergy treatments.