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Published on: September 20, 2018
Final adult height in childhood-onset inflammatory bowel disease
Andrea Taddio1,2, Gabriele Cont3, Eva DA Dalt4
1Institute for Maternal and Child Health, Burlo Garofolo IRCCS, Trieste, Italy - andrea.taddio@burlo.trieste.it.
Insights
Most pediatric patients with inflammatory bowel disease (IBD) achieve their target final height. However, disease severity and initial growth failure are key predictors of compromised growth in children with IBD.
Area of Science:
- Pediatric Gastroenterology
- Endocrinology
- Growth and Development
Background:
- Inflammatory bowel disease (IBD) can negatively impact long-term growth in children.
- Assessing final height relative to genetic potential is crucial for managing pediatric IBD.
- Understanding growth determinants in IBD is essential for timely intervention.
Purpose of the Study:
- To evaluate the final achieved height in pediatric-onset IBD patients compared to their genetic target.
- To identify factors influencing long-term growth outcomes in this cohort.
Main Methods:
- A monocentric retrospective cohort study design was employed.
- Patients with prepubertal onset IBD were included.
- Data on clinical parameters and final height achievement were collected and analyzed.
Main Results:
- Eighty-two patients (42 Crohn's disease, 40 ulcerative colitis) were analyzed.
- Eighty-nine percent of patients reached their target final height.
- Growth failure at diagnosis and disease severity were significantly associated with failure to achieve target height.
Conclusions:
- The majority of pediatric IBD patients attain their target final height.
- Disease severity and presenting height are critical predictors of final height attainment in pediatric IBD.
Background:
Long-term growth may be compromised in patients with inflammatory bowel disease (IBD). The aims of the study were to evaluate the final height in a cohort of patients with pediatric-onset IBD with respect to genetic target and to determine factors influencing long-term growth.
Methods:
This is a monocentric retrospective cohort study. All patients with diagnosed prepubertal onset IBD were enrolled. Patients were classified into two groups on the basis of the achievement of target height at time of the last follow-up. Clinical parameters were also recorded.
Results:
Eighty-tow patients were identified: 42 with Crohn's disease (CD) and 40 with ulcerative colitis (UC). The mean age at diagnosis was 11.0 (SD 4.0) years. Eighty-nine percent of patients achieved final target height. Mean difference between final and target height was -1.2 cm (SD: 5,4). No statistical significance was detected between CD and UC patients final height (P=0.16). Growth failure at the diagnosis and disease severity were the only factors associated with final height achievement failure (P=0.001 and P=0.01 respectively).
Conclusions:
Most part of CD and UC patients achieve the target final height. Disease severity and low height at diagnosis seem to be the two best predictive factors for low final height.
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