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A model for quantifying absorption through abnormal skin.

R C Scott, P H Dugard

    The Journal of Investigative Dermatology
    |February 1, 1986
    PubMed
    Summary
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    A new in vivo model quantifies skin absorption. Abnormal skin showed significantly higher permeability to [3H]mannitol and [14C]octyl benzoate compared to normal skin.

    Area of Science:

    • Dermatology
    • Pharmacokinetics
    • Toxicology

    Background:

    • Quantitative absorption studies are established for normal skin.
    • Limited data exists on abnormal skin permeability.
    • Understanding abnormal skin absorption is crucial for drug delivery and safety.

    Purpose of the Study:

    • To develop and validate an in vivo model for quantifying chemical absorption through abnormal skin.
    • To compare the permeability of normal and abnormal rat skin to model compounds.

    Main Methods:

    • An in vivo model was designed and evaluated for quantifying skin absorption.
    • Absorption of [3H]mannitol and [14C]octyl benzoate was measured through altered rat skin.
    • Comparison of absorption rates between normal and abnormal skin.

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    Main Results:

    • [3H]Mannitol permeated normal skin significantly slower than [14C]octyl benzoate.
    • Abnormal skin exhibited markedly increased permeability to both compounds.
    • [3H]Mannitol absorption was over 100X greater, and [14C]octyl benzoate absorption was over 2X greater in abnormal skin compared to normal skin.

    Conclusions:

    • The developed in vivo model successfully quantifies absorption through abnormal skin.
    • Abnormal skin demonstrates significantly enhanced permeability to tested compounds.
    • This model provides a valuable tool for assessing dermal absorption in compromised skin conditions.