Related Experiment Video
Updated: Jan 27, 2026
06:44
Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
Published on: June 23, 2009
20.4K
[The 469th case: multiple cutaneous abscesses, pelvic mass, and lung cavities]
X Y Cao1, J L Zhao1, Y Z Zhou1
1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhonghua Nei Ke Za Zhi
|March 28, 2019
Summary
Granulomatosis with polyangiitis (GPA) can mimic multiple abscesses. Early diagnosis using anti-proteinase 3 (PR3) antibodies and prompt treatment with immunosuppressants are crucial for managing this rare systemic vasculitis.
Area of Science:
- Rheumatology
- Internal Medicine
- Pathology
Background:
- Granulomatosis with polyangiitis (GPA) is a rare systemic vasculitis.
- Diagnosis can be challenging due to non-specific symptoms.
Observation:
- A 28-year-old female presented with a two-month history of multiple abscesses and a one-month history of fever.
- Clinical findings included widespread skin abscesses, pulmonary nodules/cavities, and a vesico-cervical fistula.
- Elevated inflammatory markers (ESR, CRP, ferritin) were noted, with pathological findings of necrosis and granuloma.
Findings:
- Infectious causes were ruled out.
- Diagnosis of GPA was confirmed by positive anti-proteinase 3 (PR3) antibody.
- Treatment with glucocorticoids and immunosuppressants led to significant symptom improvement.
Implications:
- This case highlights the importance of considering systemic vasculitis in the differential diagnosis of unexplained multiple abscesses.
- Early identification and management of GPA are essential for favorable patient outcomes.
- Highlights the diagnostic utility of PR3 antibodies in complex inflammatory conditions.
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