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Updated: Jan 27, 2026
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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
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Placenta Transcriptome Profiling in Intrauterine Growth Restriction (IUGR)
Marta Majewska1, Aleksandra Lipka2, Lukasz Paukszto3
1Department of Human Physiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Warszawska Str 30, 10-082 Olsztyn, Poland. marta.majewska@uwm.edu.pl.
International Journal of Molecular Sciences
|March 29, 2019
Summary
This study reveals novel genes and pathways involved in intrauterine growth restriction (IUGR) placental pathophysiology. Understanding these genetic factors is key to improving fetal development and managing complicated pregnancies.
Area of Science:
- Genomics
- Molecular Biology
- Reproductive Medicine
Background:
- Intrauterine growth restriction (IUGR) is a critical pregnancy complication impacting fetal development.
- The genetic and transcriptomic underpinnings of IUGR in human placentas require further elucidation.
Purpose of the Study:
- To explore the transcriptomic complexity of human placentas affected by IUGR.
- To identify genes, alternative splicing events, and genetic variants implicated in IUGR pathophysiology.
Main Methods:
- RNA-sequencing (RNA-Seq) was employed to profile placental transcriptomes.
- Analysis included detection of protein-coding genes, alternative splicing (AS), single nucleotide variants (SNVs), and RNA editing sites.
- Functional enrichment analysis was performed on differentially expressed genes (DEGs).
Main Results:
- 28 DEGs were identified, with 10 upregulated and 18 downregulated in IUGR placentas.
- DEGs are primarily associated with inflammation and immune responses, potentially linking to preeclampsia.
- Specific genes involved in splicing alterations (e.g., S100A13, GPR126) were linked to angiogenic processes.
Conclusions:
- This research identifies novel dysregulated genes in IUGR placentas.
- Findings highlight the role of inflammation, immune disorders, and angiogenesis in IUGR.
- Understanding these genetic mechanisms is vital for improving placental development in complicated pregnancies.
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