Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hybrid Zones02:29

Hybrid Zones

21.8K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
21.8K
Hybridization of Atomic Orbitals I03:24

Hybridization of Atomic Orbitals I

66.6K
The mathematical expression known as the wave function, ψ, contains information about each orbital and the wavelike properties of electrons in an isolated atom. When atoms are bound together in a molecule, the wave functions combine to produce new mathematical descriptions that have different shapes. This process of combining the wave functions for atomic orbitals is called hybridization and is mathematically accomplished by the linear combination of atomic orbitals. The new orbitals that...
66.6K
Hybridization of Atomic Orbitals II03:35

Hybridization of Atomic Orbitals II

48.6K
sp3d and sp3d 2 Hybridization
48.6K
Energy-releasing Steps of Glycolysis01:28

Energy-releasing Steps of Glycolysis

146.5K
Glycolysis is divided into two phases based on whether energy is utilized or released. While the first phase consumes ATP, the second phase produces energy in the form of ATP and NADH. The energy is released over a sequence of reactions that turns G3P into pyruvate. The energy-releasing phase—steps 6-10 of glycolysis—occurs twice, once for each of the two 3-carbon sugars produced during steps 1-5 of the first phase.
The first energy-releasing step—the 6th step of glycolysis...
146.5K
Drugs Affecting Neurotransmitter Release or Uptake01:21

Drugs Affecting Neurotransmitter Release or Uptake

1.6K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.6K
ATP Energy Storage and Release01:31

ATP Energy Storage and Release

14.2K
ATP is a highly unstable molecule. Unless quickly used to perform work, ATP spontaneously dissociates into ADP and inorganic phosphate (Pi), and the free energy released during this process is lost as heat. The energy released by ATP hydrolysis is used to perform work inside the cell and depends on a strategy called energy coupling. Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions, allowing them to proceed.
One example of energy coupling using ATP involves a...
14.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chain-End Grafting of RAFT Polyelectrolyte Macroligands to Stabilize Near-Infrared-Emitting Gold Nanoclusters.

Macromolecular rapid communications·2026
Same author

Making Room at the Nanoscale: A Tangible Perspective on Surface Crowding and Molecular Design.

ACS nano·2026
Same author

The geopolitical future for chemistry.

Nature reviews. Chemistry·2026
Same author

Bringing geopolitics to the periodic table.

Nature reviews. Chemistry·2025
Same author

Soil macrofauna communities in Brazilian land-use systems.

Biodiversity data journal·2024
Same author

Waterborne Polymer Coatings with Bright Noniridescent Structural Colors.

ACS applied materials & interfaces·2023

Related Experiment Video

Updated: Jan 27, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.3K

Hybrid Mesoporous Nanoparticles for pH-Actuated Controlled Release.

José L M Gonçalves1, Carina I C Crucho2, Sérgio P C Alves3

  • 1Centro de Química Estrutural and CQFM-Institute of Nanoscience and Nanotechnology, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal. joseluis@tecnico.ulisboa.pt.

Nanomaterials (Basel, Switzerland)
|March 29, 2019
PubMed
Summary

Novel hybrid mesoporous silica nanoparticles (MSNs) with a pH-responsive polymer shell offer controlled cargo release. These nanoparticles shrink and release cargo effectively at higher pH, demonstrating potential for targeted delivery systems.

Keywords:
RAFT polymerizationcontrolled releasemesoporous silica nanoparticlespH-responsivepolymer shellsmart hybrid nanoparticles

More Related Videos

Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale
08:17

Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale

Published on: May 25, 2016

9.6K
Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

8.0K

Related Experiment Videos

Last Updated: Jan 27, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.3K
Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale
08:17

Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale

Published on: May 25, 2016

9.6K
Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

8.0K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Polymer Chemistry

Background:

  • Mesoporous silica nanoparticles (MSNs) are attractive for drug delivery due to their high surface area, tunable pores, and functionalizability.
  • Developing stimuli-responsive delivery systems is crucial for targeted and controlled release of therapeutic agents.

Purpose of the Study:

  • To develop novel hybrid mesoporous silica nanoparticles (MSNs) with a pH-responsive polymer shell for controlled cargo delivery.
  • To investigate the pH-dependent behavior and cargo release characteristics of these hybrid nanoparticles.

Main Methods:

  • Synthesis of hybrid MSNs by grafting a pH-responsive polymer shell (poly(2-(diisopropylamino)ethyl methacrylate)) onto a mesoporous silica core using RAFT polymerization.
  • Characterization of nanoparticle size changes at different pH values.
  • Evaluation of cargo release kinetics based on pH-induced polymer conformational changes and electrostatic interactions.

Main Results:

  • The hybrid nanoparticles exhibited a significant size change, from ~100 nm at pH < 6.5 to ~60 nm at pH > 6.5.
  • A very low cargo release rate was observed at acidic pH due to electrostatic interactions and extended polymer chains.
  • A large cargo release rate was achieved at basic pH, attributed to the polymer shell's coil-to-globule transition and reduced electrostatic attraction.

Conclusions:

  • The developed hybrid MSNs demonstrate excellent pH-responsive behavior for controlled cargo release.
  • The system effectively modulates cargo release based on pH changes, offering a promising platform for targeted drug delivery applications.
  • The combination of silica core properties and polymer shell responsiveness enables tunable release profiles.