Ramucirumab: the long and winding road toward being an option for mCRC treatment

Celine Debeuckelaere1, Sabina Murgioni2, Sara Lonardi2

  • 1a Department of Oncology , University Hospital Antwerp , Edegem , Belgium.

Abstract

Related Concept Videos

Three-Winding Transformers01:19

Three-Winding Transformers

Three identical single-phase transformers can be configured to form a three-phase transformer connection, which involves high-voltage and low-voltage windings. The high-voltage windings are denoted by capital letters A-B-C, while the low-voltage windings are labeled with lowercase letters a-b-c, representing their respective phases. This notation helps distinguish between the high and low voltage sides of the transformer.
In the per-unit equivalent circuit of a grounded Y-Y three-phase...
704
Design Example: Alignment of a Road Line Using GIS01:17

Design Example: Alignment of a Road Line Using GIS

The alignment of a road line using Geographic Information Systems (GIS) is a critical process in civil engineering, combining advanced technology with practical decision-making. This methodology begins with the collection of geospatial data, including information on land cover, geomorphology, drainage patterns, slope, and contour details. Such data is typically acquired through satellite imagery and GIS tools, offering a comprehensive understanding of the terrain.Once the data is gathered, it...
341
Wind Turbine Machine Models01:24

Wind Turbine Machine Models

In the growing field of wind energy, incorporating wind turbine models into transient stability analysis is essential. Induction and synchronous machines are the primary models used, with induction machines being prevalent due to their simplicity and reliability.
Induction machines interact through the rotating magnetic field generated by the stator and the rotor. The key parameter is slip, which is the difference between synchronous speed and rotor speed relative to synchronous speed. Slip is...
576
Design Example: Calculating Safe Diameter for Wind-Exposed Disc01:17

Design Example: Calculating Safe Diameter for Wind-Exposed Disc

Assessing safety in wind-exposed installations is crucial to preventing potential failures. This example explores the calculation and design adjustments needed to mount a circular disc on a building facade, where wind forces are a primary concern. A 4-meter diameter disc was initially designed as an aesthetic feature facing winds at a velocity of 25 meters per second, with an air density of 1.25 kilograms per cubic meter. Given these conditions, the drag force on the disc was determined using...
358
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.0K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
856