Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

652
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
652
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

603
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
603
Resistivity01:22

Resistivity

4.4K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.4K
Resistance01:19

Resistance

5.7K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
5.7K
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

402
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
402
Hypertension I: Introduction01:28

Hypertension I: Introduction

813
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
813

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiometabolic regulation by adipocyte-derived leptin and the brain melanocortin system.

Clinical science (London, England : 1979)·2026
Same author

Is Obesity a Major Driver of Primary Aldosteronism?

JACC. Basic to translational science·2026
Same author

Parental obesity exacerbates cognitive dysfunction and cardiac vulnerability in offspring of an Alzheimer disease model.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac oxidative stress, inflammation, and heart failure development.

Redox biology·2026
Same author

Distinct immunometabolic signatures of type 1 versus type 2 diabetes in a murine model of myocardial infarction.

Cardiovascular diabetology·2026
Same author

Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection.

Circulation research·2026

Related Experiment Video

Updated: Jan 27, 2026

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal
07:24

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal

Published on: September 12, 2025

487

Device-Based Neuromodulation for Resistant Hypertension Therapy.

Thomas E Lohmeier1, John E Hall1,2

  • 1From the Department of Physiology and Biophysics (T.E.L., J.E.H.), University of Mississippi Medical Center, Jackson.

Circulation Research
|March 29, 2019
PubMed
Summary
This summary is machine-generated.

Resistant hypertension (RHT) affects many patients despite medication. Device-based therapies like baroreflex activation and renal denervation show promise for managing RHT by targeting sympathetic activity.

Keywords:
angiotensinbaroreceptorsblood pressureclinical trialkidneysympathetic nervous system

More Related Videos

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.7K
Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.6K

Related Experiment Videos

Last Updated: Jan 27, 2026

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal
07:24

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal

Published on: September 12, 2025

487
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.7K
Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.6K

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biomedical Engineering

Background:

  • Resistant hypertension (RHT) is diagnosed in patients with uncontrolled blood pressure despite multiple medications.
  • Nonadherence and increased sympathetic activity are common in RHT.
  • Adverse cardiovascular events are prevalent in RHT patients.

Purpose of the Study:

  • To review physiological mechanisms of baroreflex activation and renal denervation (RDN) for RHT.
  • To identify patient subgroups most likely to benefit from device-based therapies.
  • To discuss challenges and future directions for RHT management.

Main Methods:

  • Review of experimental and clinical studies on baroreflex activation and RDN.
  • Analysis of physiological mechanisms underlying blood pressure reduction.
  • Evaluation of device technology modifications based on clinical trial outcomes.

Main Results:

  • Baroreflex activation and RDN demonstrate potential for lowering blood pressure in RHT.
  • Understanding physiological responses guides patient selection for these therapies.
  • Device technology has evolved, but challenges in safety and efficacy persist.

Conclusions:

  • Device-based therapies targeting sympathetic activity offer new avenues for RHT management.
  • Further research is crucial to optimize patient selection and therapeutic strategies.
  • The fate of baroreflex activation and RDN in RHT hinges on ongoing clinical evaluations.