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Comparative efficacy of six therapies for Hypopharyngeal and laryngeal neoplasms: a network meta-analysis

Juan Che1, Yanlin Wang1, Xiaolin Zhang1

  • 1Department of Otorhinolaryngology, Binzhou Medical University Hospital, No. 661 Second Huanghe Road, Binzhou, 256603, Shandong, China.

BMC Cancer
|March 30, 2019
PubMed
Abstract

Insights

Radiotherapy combined with surgery is the most effective treatment for hypopharyngeal and laryngeal neoplasms. Other therapies like induction chemoradiotherapy (ICRT) and current chemoradiotherapy (CCRT) also show promise for disease-free survival.

Area of Science:

  • Oncology
  • Head and Neck Cancers
  • Treatment Efficacy

Background:

  • Hypopharyngeal and laryngeal neoplasms are aggressive cancers often diagnosed late.
  • Optimal treatment strategies for these cancers remain unclear.
  • This study addresses the need for comparative effectiveness research in head and neck oncology.

Purpose of the Study:

  • To compare the efficacy of six contemporary therapies for hypopharyngeal and laryngeal neoplasms.
  • To identify the most effective treatment regimens based on survival outcomes.

Main Methods:

  • A network meta-analysis (NMA) was performed using data from PubMed and Embase.
  • Direct and indirect treatment evidence was synthesized.
  • The Surface Under the Curve ranking area (SUCRA) was used to rank treatment efficacy.

Main Results:

  • Twenty-eight trials involving 9109 patients were analyzed.
  • Radiotherapy plus surgery (RT+S) demonstrated superior overall survival (OS) and disease-free survival (DFS) compared to other treatments.
  • Induction chemoradiotherapy (ICRT) and current chemoradiotherapy (CCRT) showed high rankings for DFS.

Conclusions:

  • Radiotherapy combined with surgery (RT+S) is the optimal therapeutic approach for hypopharyngeal and laryngeal neoplasms.
  • CCRT and ICRT are recommended as secondary treatment options due to their favorable DFS.
  • Radiotherapy alone showed poorer efficacy in advanced laryngeal and hypopharyngeal stages.
Keywords:
EfficacyHypopharyngeal neoplasmLaryngeal neoplasmNetwork meta-analysis

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