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Updated: Jan 27, 2026

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
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Perceived fatigue in myotonic dystrophy type 1: a case-control study.

Stefan Winblad1, Christopher Lindberg2,3

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|March 30, 2019
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Summary

Patients with Myotonic Dystrophy type 1 (DM1) experience significantly higher fatigue levels compared to healthy individuals. This fatigue is linked to increased muscle impairment and depression, impacting daily functioning.

Keywords:
CognitionDepressionFatigueMyotonic dystrophyNeuromuscular

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Area of Science:

  • Neurology
  • Clinical Medicine
  • Patient-Reported Outcomes

Background:

  • Myotonic Dystrophy type 1 (DM1) is a genetic disorder affecting muscle function.
  • Fatigue is a common but understudied symptom in DM1 patients.
  • Understanding fatigue correlates is crucial for improving patient quality of life.

Purpose of the Study:

  • To investigate perceived fatigue in DM1 patients.
  • To identify functional limitations associated with fatigue in DM1.
  • To explore clinical factors correlating with fatigue in DM1.

Main Methods:

  • 32 DM1 patients and 30 healthy controls completed the Fatigue Impact Scale (FIS).
  • Assessments included CTG-repeat size, muscle impairment, depression, and cognitive function.
  • Non-parametric statistical analyses (Mann-Whitney U-test, Spearman correlation) were employed.

Main Results:

  • DM1 patients reported significantly higher overall fatigue (FIS total score) than controls.
  • DM1 patients showed higher scores on the physical and psychosocial FIS subscales, but not the cognitive subscale.
  • Fatigue scores strongly correlated with muscle impairment and depression severity.

Conclusions:

  • Perceived fatigue is a prevalent issue in Myotonic Dystrophy type 1.
  • Depression and muscle impairment are significant clinical correlates of fatigue in DM1.
  • Addressing depression and muscle impairment may help alleviate fatigue in DM1 patients.