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Updated: Jan 27, 2026
Culture and Co-Culture of Mouse Ovaries and Ovarian Follicles
Published on: March 17, 2015
MTHFR C677T polymorphism is associated with follicle-stimulating hormone levels and controlled ovarian
Shuangshuang Zeng1, Xiang Wang1, Yonggang Wang2
1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Objective:
To evaluate the impact of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with clinical data analysis in controlled ovarian hyperstimulation (COH) of infertile women in the Intravenous Infusion Safety Evaluation Center of Hunan Province, People's Republic of China.
Design:
Genetic Association Study.
Setting:
Reproductive medicine clinical.
Patient(S):
This genetic association study included 722 infertile women who received the standard long treatment protocol with accessible and complete electronic medical records.
Intervention(S):
None.
Main Outcome Measure(S):
The clinical parameters were obtained from the Intravenous Infusion Safety Evaluation center.
Result(S):
Basal FSH levels in the TT group were significantly higher than those of the CC group. The FSH levels after down-regulation in the TT group were higher than those of CC/CT genotypes. The TT genotype patients received significantly higher total doses of GnRH agonist and FSH compared with CC/CT genotypes, whereas the total dose of hCG was higher in the CT genotypes compared with the CC/TT genotypes. Further association analysis between hormone levels and COH outcomes indicated significantly negative correlation of basal FSH levels with antral follicle count and number of oocytes as well as the down-regulation FSH levels with the number of metaphase II oocytes and oocytes.
Conclusion(S):
The MTHFR C677T polymorphism was associated with high doses of ovarian stimulation medications, as well as higher FSH levels. The negative correlation between FSH levels and the number of oocytes suggested that C677T polymorphism may play a role in the poor prognosis of COH oocytes. This needs to be studied in future prospective studies with longer follow-up.
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