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Updated: Jan 27, 2026

Visualizing Dengue Virus through Alexa Fluor Labeling
Published on: July 9, 2011
Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon
Yuen P Tan1, Sevan D Houston1, Naphak Modhiran2
1School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072, Queensland, Australia.
Abstract:
Stachyonic acid A, arising from the first in-depth phytochemical investigation of the herb Basilicum polystachyon, was found to display potent inhibitory activity against dengue virus, with limited cytotoxicity. Andrographolide, a known dengue virus inhibitor and closely related labdane-type diterpene, is structurally more complex but displayed poor antiviral activity in the PRNT assay, and increased cytotoxicity in comparison. Furthermore, a Diels-Alder reaction with PTAD identified the active pharmacophore of stachyonic acid to be the conjugated diene.
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