Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

4.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K
Understanding the Self01:28

Understanding the Self

251
The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
251
Understanding Memory01:19

Understanding Memory

1.4K
Memory is the retention of information or experiences over time, facilitated through three main processes: encoding, storage, and retrieval. Encoding is the process of inputting information into the memory system. For instance, when listening to a lecture, watching a play, reading a book, or having a conversation, the brain is actively encoding information. This initial stage involves transforming sensory input into a form that can be processed and stored by the brain. Various factors, such as...
1.4K
Understanding Love01:27

Understanding Love

183
Love, as a multifaceted psychological construct, encompasses emotions, cognitive processes, and behavioral patterns that play a crucial role in human relationships. It extends beyond attraction, manifesting in deep, enduring connections that influence personal well-being and social structures.Psychological Dimensions of LoveLove differs from friendship and mere liking through its depth and intensity. While friendship is built on mutual respect, trust, and companionship, love involves emotional...
183
Understanding Consciousness01:23

Understanding Consciousness

1.8K
Consciousness can be defined as the state of being aware of and able to think about one's existence, sensations, and surroundings. It encompasses two major components: awareness and arousal. Awareness pertains to the recognition of environmental stimuli and internal states. At the same time, arousal refers to the physiological readiness to engage with these stimuli, which varies significantly between states like sleep and wakefulness.
Sleep, a crucial state, is characterized by reduced...
1.8K
Understanding Sleep01:11

Understanding Sleep

1.4K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline TRI-SCORE for risk stratification before tricuspid transcatheter edge-to-edge repair: A systematic review and meta-analysis.

Cardiovascular revascularization medicine : including molecular interventions·2026
Same author

Conduction System Pacing vs Right Ventricular Pacing in Preserved or Mildly Reduced Ejection Fraction: A Meta-Analysis of Randomised Trials.

The Canadian journal of cardiology·2026
Same author

Beta-Blockers After Myocardial Infarction Without Reduced Ejection Fraction: A Meta-Analysis of Kaplan-Meier Reconstructed Individual Patient Data.

American journal of cardiovascular drugs : drugs, devices, and other interventions·2026
Same author

The Atypical Presentation and Delayed Timing of Anastomotic Leak in Patients Who Undergo Cytoreducation and Hyperthermic Intraperitoneal Chemotherapy.

The Journal of surgical research·2025
Same author

Cardiovascular toxicity of Fruquintinib in patients with colorectal and other cancers: a systematic review and meta-analysis.

Cardio-oncology (London, England)·2025
Same author

Predictors of Post-TAVR Left Bundle Branch Block: A Systematic Review and Meta-Analysis.

Journal of cardiovascular electrophysiology·2025

Related Experiment Video

Updated: Jan 27, 2026

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy
05:20

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

Published on: June 29, 2021

3.4K

Understanding the marvels behind liver regeneration.

Anan Abu Rmilah1, Wei Zhou1, Erek Nelson1

  • 1Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, Minnesota.

Wiley Interdisciplinary Reviews. Developmental Biology
|March 30, 2019
PubMed
Summary

Liver regeneration restores damaged tissue through initiation, proliferation, and termination phases. Understanding these molecular signals is key to developing new therapies for liver failure.

Keywords:
hepatic progenitor cellliver regenerationpartial hepatectomy

More Related Videos

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration
05:37

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Published on: May 31, 2018

12.7K
Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration
08:14

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration

Published on: May 20, 2015

9.1K

Related Experiment Videos

Last Updated: Jan 27, 2026

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy
05:20

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

Published on: June 29, 2021

3.4K
Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration
05:37

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Published on: May 31, 2018

12.7K
Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration
08:14

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration

Published on: May 20, 2015

9.1K

Area of Science:

  • Regenerative Medicine
  • Molecular Biology
  • Stem Cell Biology

Background:

  • Tissue regeneration, a fundamental biological process, involves the regrowth of cells in injured organs.
  • Liver regeneration is a critical area of research for treating liver failure, with extensive studies in rodent models.
  • The process is complex, involving distinct phases and intricate molecular control mechanisms.

Purpose of the Study:

  • To provide a comprehensive review of human liver function, anatomy, and regeneration.
  • To elucidate the molecular mechanisms, cellular lineages, and signaling pathways governing liver regeneration.
  • To explore the role of hepatic progenitor cells in restoring liver structure and function.

Main Methods:

  • Review of existing literature on liver regeneration, including molecular and cellular aspects.
  • Analysis of the three distinct phases of liver regeneration: initiation, proliferation, and termination.
  • Discussion of signaling pathways, growth factors, and regulatory molecules involved.

Main Results:

  • Liver regeneration involves a precisely regulated three-phase process: initiation, proliferation, and termination.
  • Hepatocyte and cholangiocyte lineages play crucial roles in mediating liver regeneration.
  • Hepatic progenitor cells, signaling pathways, and specific molecules are essential for complete liver restoration.

Conclusions:

  • Understanding the molecular basis of liver regeneration is vital for developing novel therapeutic strategies for liver diseases.
  • The review synthesizes current knowledge on liver regeneration, highlighting key cellular and molecular players.
  • Further research into regenerative signaling pathways can lead to advancements in tissue engineering and treatments for liver failure.