Complete blood count parameters in peripheral arterial disease

Area of Science:

• Cardiology
• Hematology
• Inflammation Research

Background:

• Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis.
• Inflammation plays a crucial role in the pathogenesis and progression of PAD.
• Identifying reliable biomarkers for inflammation in PAD is essential for effective management.

Purpose of the Study:

• To investigate the potential of complete blood count (CBC) parameters as biomarkers of inflammation in patients with PAD.
• To compare CBC parameters between PAD patients and healthy controls.
• To identify independent predictors of PAD among CBC parameters.

Main Methods:

• A retrospective study involving 75 patients with PAD and 75 healthy controls.
• Comparison of baseline clinical characteristics and laboratory data, including C-reactive protein (CRP), white blood cell (WBC) count, neutrophil-to-lymphocyte ratio (NLR), and mean platelet volume (MPV).
• Statistical analysis included univariate tests (t-test, Mann-Whitney U, chi-square) and multivariate logistic regression.

Main Results:

• While CRP, WBC, and NLR were higher in the PAD group, they were not independent predictors of PAD.
• Mean platelet volume (MPV) was found to be a statistically significant independent predictor of PAD.
• Demographic and clinical features were similar between the PAD and control groups.

Conclusions:

• Mean platelet volume (MPV) is an independent predictor of peripheral arterial disease (PAD).
• MPV may serve as a valuable marker of inflammation in patients with PAD.
• Further research can explore the therapeutic implications of targeting inflammation through MPV-related pathways in PAD.