Related Experiment Video

Updated: Jan 27, 2026

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

771

Optimization of therapies for men with advanced prostate cancer: a review of recent developments with a look toward

Theodore Gourdin1

  • 1Department of Medicine - Division of Hematology Oncology, Medical University of South Carolina, South Carolina, USA.

Current Opinion in Oncology
|March 30, 2019
PubMed
Abstract

Insights

Treatment for advanced prostate cancer is rapidly advancing. New therapies, including targeted treatments and immunotherapies, offer improved options for patients with castration-resistant disease.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Advanced prostate cancer treatment is evolving rapidly.
  • Optimal sequencing of therapies for metastatic castration-sensitive prostate cancer (mCSPC) remains under investigation, with focus on abiraterone and docetaxel.
  • Next-generation antiandrogens show promise in nonmetastatic castration-resistant prostate cancer (nmCRPC).

Purpose of the Study:

  • To review recent advancements in the treatment of advanced prostate cancer.
  • To highlight research optimizing current therapies and exploring novel treatment strategies.
  • To discuss individualized approaches targeting specific genomic anomalies and refractory disease.

Main Methods:

  • Review of recent randomized trials and clinical findings.
  • Analysis of therapeutic sequencing in mCSPC and nmCRPC.
  • Exploration of novel agents including poly(ADP-ribose) polymerase inhibitors, radiopharmaceuticals, and immunotherapies.

Main Results:

  • Abiraterone and docetaxel are being utilized earlier in mCSPC treatment.
  • Next-generation antiandrogens demonstrate potential in nmCRPC.
  • Genomic anomalies, particularly DNA repair defects, are targets for poly(ADP-ribose) polymerase inhibitors.
  • Steroid adjustments may enhance abiraterone efficacy.
  • Novel radiopharmaceuticals and immunotherapies are emerging for castration-resistant prostate cancer.

Conclusions:

  • Therapeutic strategies for advanced prostate cancer are becoming more sophisticated and individualized.
  • Earlier intervention with established and novel agents is improving outcomes.
  • Targeted therapies, radiopharmaceuticals, and immunotherapies represent the future of advanced prostate cancer treatment, especially for refractory disease.

More Related Videos

Focal Laser Ablation of Prostate Cancer: An Office Procedure11:07

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

8.4K
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.7K
Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.3K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
10.9K
Sustainable Development01:43

Sustainable Development

As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
14.8K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K