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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.6K

Percentile curves for left ventricle structural, functional and haemodynamic parameters obtained in healthy children

Alejandro Díaz1, Yanina Zócalo2, Daniel Bia2

  • 1Instituto de Investigación en Ciencias de La Salud, UNICEN-CONICET, 4 de Abril 618, 7000, Tandil, Buenos Aires Province, Argentina. alejandrounicen@gmail.com.

Journal of Echocardiography
|March 31, 2019
PubMed

Insights

This study establishes reference intervals for echocardiography measurements in young South Americans. These findings provide crucial data for interpreting left ventricle and aortic parameters in children and adolescents.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Medical Imaging

Background:

  • Transthoracic echocardiography is a key non-invasive tool for assessing the left ventricle (LV) and aorta.
  • Population-based reference intervals (RIs) for pediatric echocardiographic parameters are scarce.
  • This study addresses the need for RIs in a South American pediatric and young adult population.

Purpose of the Study:

  • To generate reference intervals (RIs) and percentiles for thoracic aorta dimensions and LV structural/functional parameters.
  • To establish age, body size, and sex-specific RIs for echocardiographic measurements in healthy children, adolescents, and young adults.
  • To provide a comprehensive dataset for accurate interpretation of echocardiographic findings in a South American population.

Main Methods:

  • 1095 healthy subjects aged 5-24 years underwent M-mode, B-mode, and Doppler echocardiography.
  • Parametric regression analyses, including fractional polynomials, were used to derive RIs.
  • Covariate analysis confirmed the necessity of sex-specific RIs, adjusting for age and body surface area.

Main Results:

  • Established RIs for LV structural (diameters, volumes, wall thickness) and functional (stroke volume, cardiac output, cardiac index, E/A waves) parameters.
  • Generated RIs for systemic vascular resistance and aortic root diameter.
  • Provided age, body height, body weight, body surface area, and sex-specific percentiles (1st to 99th).

Conclusions:

  • This study presents the largest Argentinean database for echocardiography-derived RIs in children, adolescents, and young adults.
  • Accurate interpretation of echocardiographic LV and aortic parameters necessitates considering age, body size, and sex-specific RIs.
  • The findings complement existing international databases and enhance clinical practice.
Abstract

Keywords:
Cardiac indexCardiac outputLeft ventricular dimensionsLeft ventricular functionPediatricsPercentiles

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