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Updated: Jan 27, 2026

Interview: HIV-1 Proviral DNA Excision Using an Evolved Recombinase
Published on: June 16, 2008
Routine drug resistance testing in proviral HIV-1 DNA: Prevalence of stop codons and hypermutation, and associated
Enagnon Kazali Alidjinou1, Joséphine Deldalle1, Olivier Robineau2
1Faculté de Médecine, CHU Lille, Laboratoire de Virologie EA3610, Univ Lille, Lille, France.
Abstract:
We investigated the presence of stop codons (SC) and/or hypermutation (HM) in HIV-1 DNA sequences generated for routine drug resistance testing in proviral HIV-1 DNA, and sought for associated factors. At least one SC was identified in 6.2% of HIV-1 DNA sequences, among which 54.8% were hypermutated. The defective virus group (SC w/o HM) was similar to the non-SC group regarding the characteristics of HIV-1 infection, and before drug exposure. In addition, the HIV-1 DNA levels were not different between both groups. Sequences with SC/HM displayed a higher proportion of RAMs. The impact of the SC/HM associated RAMs on clinical responses requires further investigation.
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