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Single-cell Microinjection for Cell Communication Analysis

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Published on: February 26, 2017

Mechanical Communication Acts as a Noise Filter.

Hen Viner¹, Ido Nitsan¹, Liel Sapir¹

¹Faculty of Mechanical Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel.

|March 31, 2019

Summary

Mechanical cell coupling reduces cellular noise. This interaction between beating cardiac cells and even artificial mechanical cells demonstrates a novel signaling pathway that stabilizes cellular function, mediated by key cellular components.

Keywords:

Biological Sciences: cell biology Physical sciences: biophysics cardiac biology cell mechanics

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Area of Science:

Cellular Biology
Biophysics
Systems Biology

Background:

Cells communicate mechanically through physical deformations.
Mechanical coupling's role in cellular signaling is not fully understood.
Intrinsic cellular noise can impact biological function.

Purpose of the Study:

To investigate the role of mechanical communication in reducing intrinsic cellular noise.
To quantify the relationship between mechanical coupling strength and noise reduction.
To identify the molecular mediators of noise reduction via mechanical coupling.

Main Methods:

Culturing beating cardiac cells on a patterned flexible substrate to measure mechanical interactions.
Developing an artificial 'mechanical cell' to isolate the effects of mechanical coupling.
Analyzing beat-to-beat variability to quantify cellular noise.
Assessing the involvement of microtubule integrity, NOX2, and CaMKII.

Main Results:

Mechanical coupling between cells significantly reduces intrinsic noise.
Cellular noise decays exponentially with increasing mechanical coupling strength.
Noise reduction persists even after mechanical stimulation ceases.
Microtubule integrity, NOX2, and CaMKII were identified as key mediators.

Conclusions:

Mechanical coupling serves as a crucial signaling mechanism that stabilizes cellular function by reducing intrinsic noise.
This noise reduction is a direct consequence of physical interactions between cells.
The identified mediators provide potential targets for modulating cellular stability.