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Updated: Jan 27, 2026

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Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments
Published on: May 26, 2019
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Characterizing a Geant4 Monte Carlo model of a multileaf collimator for a TrueBeam™ linear accelerator
Praneeth Kandlakunta1, Shadab Momin1, Austin Sloop1
1Department of Radiation Oncology, Washington University in St. Louis School of Medicine, St Louis, MO, USA.
Summary
A Geant4 Monte Carlo model of the TrueBeam™ linear accelerator
Area of Science:
- Medical Physics
- Radiation Oncology
- Computational Dosimetry
Background:
- Accurate modeling of linear accelerators (linacs) is crucial for radiation therapy.
- The TrueBeam™ linac with its multileaf collimator (MLC) is widely used in clinical practice.
Purpose of the Study:
- To develop and validate a Geant4 Monte Carlo (MC) model of a TrueBeam™ linac with a 120-leaf Millennium™ MLC.
- To assess the dosimetric characteristics of the modeled MLC.
Main Methods:
- A Geant4 application was created to simulate the TrueBeam™ linac geometry and materials.
- The Varian 120-leaf Millennium™ MLC was modeled, incorporating features like tongue-groove design.
- Simulated dose profiles and depth-doses were compared against experimental data for validation.
Main Results:
- Depth dose curves showed excellent agreement (within 1-2%) with experimental data across various field sizes.
- Cross-plane dose profiles demonstrated good agreement (<2% up to 10 cm depth, <4% beyond).
- MLC dosimetric characterization, including leakage and penumbra, aligned well with film measurements.
Conclusions:
- A validated Geant4 MC model of the TrueBeam™ linac with a 120-leaf MLC was successfully developed.
- The model's accuracy was confirmed through comparison with experimental measurements.
- This validated model can be used for independent dose verification and quality assurance (QA) in intensity-modulated radiation therapy (IMRT).
Keywords:
Dynamic simulationGeant4 toolkitLinear acceleratorMonte Carlo modelingMultileaf collimatorPhase spaceMore Related Videos
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