Changes in tissue gadolinium biodistribution measured in an animal model exposed to four chelating agents
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Updated: Jan 27, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Türker Acar1,2, Egemen Kaya3, Mustafa Deniz Yoruk4
1Department of Radiology, University of Health Sciences Bozyaka Education and Training Hospital, Saim Cikrici cd. No: 59 S.B.U. Bozyaka Egitim ve Arastirma Hastanesi Karabaglar, Izmir, Turkey. drtacar@hotmail.com.
Purpose:
This study investigated the potential to reduce gadolinium levels in rodents after repetitive IV Gadodiamide administration using several chelating agents.
Materials And Methods:
The following six groups of rats were studied. Group 1: Control; Group 2: Gadodiamide only; Group 3: Meso-2,3-Dimercaptosuccinic acid (DMSA) + Gadodiamide; Group 4: N-Acetyl-L-cysteine (NAC) + Gadodiamide; Group 5: Coriandrum sativum extract + Gadodiamide; and Group 6: Deferoxamine + Gadodiamide. Brain, kidney, and blood samples were evaluated via inductively coupled plasma mass spectrometry. The brain was also evaluated histologically.
Results:
Kidney gadolinium levels in Groups 4 and 5 were approximately double that of Group 2 (p = 0.033 for each). There was almost no calcification in rat hippocampus for Group 4 rodents when compared with Groups 2, 3, 5 and 6.
Conclusion:
Our preliminary study shows that excretion to the kidney has a higher propensity in NAC and Coriandrum sativum groups. It may be possible to change the distribution of gadolinium by administrating several agents. NAC may lower Gadodiamide-induced mineralization in rat hippocampus.
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