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Updated: Jan 27, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Changes in tissue gadolinium biodistribution measured in an animal model exposed to four chelating agents
Türker Acar1,2, Egemen Kaya3, Mustafa Deniz Yoruk4
1Department of Radiology, University of Health Sciences Bozyaka Education and Training Hospital, Saim Cikrici cd. No: 59 S.B.U. Bozyaka Egitim ve Arastirma Hastanesi Karabaglar, Izmir, Turkey. drtacar@hotmail.com.
Purpose:
This study investigated the potential to reduce gadolinium levels in rodents after repetitive IV Gadodiamide administration using several chelating agents.
Materials And Methods:
The following six groups of rats were studied. Group 1: Control; Group 2: Gadodiamide only; Group 3: Meso-2,3-Dimercaptosuccinic acid (DMSA) + Gadodiamide; Group 4: N-Acetyl-L-cysteine (NAC) + Gadodiamide; Group 5: Coriandrum sativum extract + Gadodiamide; and Group 6: Deferoxamine + Gadodiamide. Brain, kidney, and blood samples were evaluated via inductively coupled plasma mass spectrometry. The brain was also evaluated histologically.
Results:
Kidney gadolinium levels in Groups 4 and 5 were approximately double that of Group 2 (p = 0.033 for each). There was almost no calcification in rat hippocampus for Group 4 rodents when compared with Groups 2, 3, 5 and 6.
Conclusion:
Our preliminary study shows that excretion to the kidney has a higher propensity in NAC and Coriandrum sativum groups. It may be possible to change the distribution of gadolinium by administrating several agents. NAC may lower Gadodiamide-induced mineralization in rat hippocampus.
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