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The Arch of Aorta01:10

The Arch of Aorta

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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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Hybrid Zones02:29

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Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
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Base Excision Repair01:54

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Related Experiment Video

Updated: Jan 27, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

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Hybrid Aortic Arch Repairs.

Kiyofumi Morishita1

  • 1Department of Cardiovascular Surgery, Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan.

Annals of Vascular Diseases
|April 2, 2019
PubMed
Summary

Hybrid aortic arch repair (HAAR) offers a viable option for high-risk patients, with a 3% 30-day mortality. Ongoing technique refinement aims to minimize late endograft complications.

Area of Science:

  • Vascular Surgery
  • Cardiovascular Interventions

Background:

  • Hybrid aortic arch repair (HAAR) combines thoracic stent-graft procedures with techniques to preserve cerebral blood flow.
  • Various HAAR methods exist, including arch artery debranching and endograft fenestration/branching.

Purpose of the Study:

  • To review existing literature and present clinical experience with hybrid aortic arch repair.
  • To evaluate the outcomes and complications associated with HAAR.

Main Methods:

  • Retrospective review of literature.
  • Analysis of clinical data from 172 patients who underwent HAAR.

Main Results:

  • 30-day mortality was 3% (5/172).
  • Complications included persistent neurologic deficits (4%), respiratory failure (3%), de novo aortic dissection (3%), spinal cord injury (2%), and type Ia endoleak (17%).
Keywords:
branched endograftdebranchingfenestrationhybrid aortic arch repairparallel graft technique

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  • Seventeen patients required reintervention, and 56 late deaths occurred, with 9 being aortic-related.

    • Conclusions:

    • Hybrid arch debranching repair is suitable for elderly or high-surgical-risk patients.
    • Further advancements in techniques and device technology are needed to reduce late endograft-related events.