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Updated: Jan 27, 2026

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Published on: January 27, 2023
Acute Colchicine-induced Neuromyopathy in a Patient Treated with Atorvastatin and Clarithromycin
José M Olmos-Martínez1, Helena Molina2, Cristina Salas2
1Gastroenterology and Hepatology Department, Hospital Universitario Marqués de Valdecilla-IDIVAL, Universidad de Cantabria, Santander, Spain.
Abstract:
Neuromyopathy is a rare side effect of chronic colchicine therapy, especially without renal impairment. Drugs interacting with colchicine metabolism through CYP3A4 can accelerate accumulation and toxicity. We describe a case of an interaction between atorvastatin, clarithromycin and colchicine resulting in acute neuromyopathy.
Learning Points:
Colchicine has a narrow therapeutic window, and therefore, often produces side effects.Special caution should be adopted if patients with renal disease and concomitant medications are given colchicine.Before prescribing colchicine, the clinical history, including previous medications and conditions, should be carefully considered.
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