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Related Experiment Videos

Visual Dysfunction in Huntington's Disease: A Systematic Review.

Amit Dhalla1, Susil Pallikadavath1, Claire V Hutchinson2

  • 1School of Medicine, College of Life Sciences, University of Leicester, Leicester, UK.

Journal of Huntington'S Disease
|April 2, 2019
PubMed
Summary
This summary is machine-generated.

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Huntington's disease (HD) causes visual pathway damage, affecting sight. Early visual processing and perception, especially color and motion, are impaired in HD patients.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Genetics

Background:

  • Huntington's disease (HD) is known to cause cognitive deficits.
  • Emerging evidence suggests HD also impacts basic sensory visual processing.

Purpose of the Study:

  • To review evidence on how HD affects early visual pathways and low-level visual sensitivity.
  • To consolidate findings on structural and functional changes in the visual system due to HD.

Main Methods:

  • Literature review of studies investigating visual processing in Huntington's disease patients.
  • Analysis of evidence for structural changes (e.g., retinal thinning, cell loss) and functional deficits (e.g., VEP amplitude).

Main Results:

  • Evidence indicates reduced structural and functional integrity of visual pathways in HD.
Keywords:
Huntington’s diseasecolour visioncontrast sensitivitymotion perceptionprimary visual cortexretinavisionvisual pathways

Related Experiment Videos

  • Specific findings include retinal thinning, reduced VEP amplitude, and visual cortex cell loss.
  • Deficits in color and motion perception are also observed.

    • Conclusions:

    • HD impacts both the structure and function of the early visual system.
    • Further research is needed to correlate visual system changes with perceptual deficits and disease severity in HD.