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Updated: Jan 27, 2026
08:55
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
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Hibernoma Demonstrated on 68Ga-DOTATATE PET/CT
Clinical Nuclear Medicine
|April 2, 2019
Summary
Hibernoma, a benign tumor, can mimic neuroendocrine tumors on Gallium-68 DOTATATE PET/CT scans. This case highlights hibernoma as a source of false-positive intraosseous uptake, impacting diagnostic accuracy.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Neuroendocrine tumors (NETs) are often evaluated using Gallium-68 DOTATATE Positron Emission Tomography/Computed Tomography (Ga-DOTATATE PET/CT).
- Accurate staging and characterization of NETs are crucial for effective treatment planning.
Observation:
- A 60-year-old woman with newly diagnosed NETs presented for staging Ga-DOTATATE PET/CT.
- The scan identified focal uptake in the right sacral ala, an unusual location for NET metastasis.
Findings:
- Histopathological examination of the right sacral ala revealed hibernoma, a benign brown adipose tissue tumor.
- This finding indicates that hibernoma can lead to false-positive intraosseous Ga-DOTATATE uptake.
Implications:
- Hibernoma should be considered in the differential diagnosis of intraosseous Ga-DOTATATE uptake in patients with NETs.
- Awareness of this potential pitfall can prevent misdiagnosis and unnecessary interventions.
- Further research may explore specific imaging characteristics to differentiate hibernoma from true osseous metastases.
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