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Children with dyskinetic cerebral palsy are severely affected as compared to bilateral spastic cerebral palsy

Marie Préel1, Gija Rackauskaite2, Mads L Larsen3

  • 1Department of Paediatrics, Copenhagen University Hospital, Hillerød, Denmark.

Acta Paediatrica (Oslo, Norway : 1992)
|April 2, 2019
PubMed

Insights

Children with dyskinetic cerebral palsy (CP) face more severe neurodevelopmental impairments and adverse perinatal events compared to those with bilateral spastic CP. This highlights key differences in clinical findings and risk factors for these CP subtypes.

Area of Science:

  • Neurology
  • Pediatrics
  • Developmental Pediatrics

Background:

  • Cerebral palsy (CP) is a group of movement disorders.
  • Dyskinetic CP and bilateral spastic CP are distinct subtypes with varying clinical presentations.
  • Understanding differences is crucial for targeted interventions.

Purpose of the Study:

  • To compare clinical findings in children with dyskinetic CP versus bilateral spastic CP.
  • To identify distinct perinatal risk factors and neurodevelopmental outcomes.

Main Methods:

  • Data from the Danish nationwide CP register (1999-2007 births).
  • Analysis of 92 dyskinetic CP cases and 540 bilateral spastic CP cases.
  • Comparison of perinatal factors, motor function, and associated impairments.

Main Results:

  • Dyskinetic CP showed higher rates of low Apgar scores and neonatal seizures.
  • More severe gross motor function impairment (GMFCS levels III-V) in dyskinetic CP (90.0% vs. 66.0%).
  • Higher prevalence of basal ganglia lesions (27.7% vs. 12.8%) and severe neurodevelopmental issues (developmental quotient, visual impairment, epilepsy) in dyskinetic CP.

Conclusions:

  • Dyskinetic CP and bilateral spastic CP share some features but differ in perinatal risks.
  • Children with dyskinetic CP experienced more adverse peri- or neonatal events.
  • Severe neurodevelopmental impairment is characteristic of dyskinetic CP.
Abstract

Keywords:
Cerebral palsyDyskineticPaediatricPrevalenceSpasticity

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