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Trimethoprim in enteric fever
The Journal of Antimicrobial Chemotherapy
|August 1, 1986
Abstract:
Seventy-one patients suffering from typhoid or paratyphoid fever were treated with trimethoprim. Sixty-three were cured. Only three patients continued to excrete Salmonella typhi in stools at the time of discharge from hospital. Trimethoprim alone is a suitable agent for the treatment of enteric fever.
Insights
Trimethoprim effectively treated typhoid and paratyphoid fever in seventy-one patients. This antibiotic proved suitable for enteric fever, with most patients cured and few continuing to excrete Salmonella typhi.
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Background:
- Enteric fever, including typhoid and paratyphoid fever, poses a significant global health challenge.
- Antimicrobial resistance necessitates the evaluation of effective treatment options for Salmonella infections.
Purpose of the Study:
- To assess the efficacy of trimethoprim as a monotherapy for treating typhoid and paratyphoid fever.
- To determine the clinical and microbiological cure rates in patients receiving trimethoprim.
Main Methods:
- A clinical study involving seventy-one patients diagnosed with typhoid or paratyphoid fever.
- Treatment administered using trimethoprim as the sole antimicrobial agent.
- Monitoring of clinical recovery and fecal excretion of Salmonella typhi post-treatment.
Main Results:
- Sixty-three out of seventy-one patients achieved a clinical cure.
- Only three patients remained positive for Salmonella typhi in stool samples upon hospital discharge.
- Trimethoprim demonstrated a high success rate in eradicating the pathogen.
Conclusions:
- Trimethoprim monotherapy is a viable and effective treatment strategy for enteric fever.
- The study supports the use of trimethoprim for managing typhoid and paratyphoid fever, with favorable clinical outcomes.
- Further research may explore long-term efficacy and resistance patterns.