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Trimethoprim in enteric fever.

P Gargalianos, P T Jackson, C Herzog

The Journal of Antimicrobial Chemotherapy

|August 1, 1986

Summary

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Trimethoprim effectively treated typhoid and paratyphoid fever in seventy-one patients. This antibiotic proved suitable for enteric fever, with most patients cured and few continuing to excrete Salmonella typhi.

Area of Science:

Infectious Diseases
Microbiology
Pharmacology

Background:

Enteric fever, including typhoid and paratyphoid fever, poses a significant global health challenge.
Antimicrobial resistance necessitates the evaluation of effective treatment options for Salmonella infections.

Purpose of the Study:

To assess the efficacy of trimethoprim as a monotherapy for treating typhoid and paratyphoid fever.
To determine the clinical and microbiological cure rates in patients receiving trimethoprim.

Main Methods:

A clinical study involving seventy-one patients diagnosed with typhoid or paratyphoid fever.
Treatment administered using trimethoprim as the sole antimicrobial agent.
Monitoring of clinical recovery and fecal excretion of Salmonella typhi post-treatment.

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Main Results:

Sixty-three out of seventy-one patients achieved a clinical cure.
Only three patients remained positive for Salmonella typhi in stool samples upon hospital discharge.
Trimethoprim demonstrated a high success rate in eradicating the pathogen.

Conclusions:

Trimethoprim monotherapy is a viable and effective treatment strategy for enteric fever.
The study supports the use of trimethoprim for managing typhoid and paratyphoid fever, with favorable clinical outcomes.
Further research may explore long-term efficacy and resistance patterns.