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A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement
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High-Intensity Interval Training is Associated with Improved Long-Term Survival in Heart Failure Patients

Chih-Chin Hsu1,2,3, Tieh-Cheng Fu4,5,6, Shin-Sheng Yuan7

  • 1Department of Physical Medicine and Rehabilitation, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan. steele0618@gmail.com.

Journal of Clinical Medicine
|April 3, 2019
PubMed

Insights

High-intensity interval training (HIIT) significantly improves survival in heart failure (HF) patients by increasing peak oxygen consumption (VO2peak) and improving left ventricle dimensions. This exercise intervention offers a promising strategy for enhancing outcomes in HF management.

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Heart Failure Management

Background:

  • Heart failure (HF) is a chronic condition associated with significant mortality.
  • Exercise-based interventions are explored to improve outcomes in HF patients.
  • Left ventricle (LV) dimensions and peak oxygen consumption (VO2peak) are key indicators of HF prognosis.

Purpose of the Study:

  • To investigate the impact of high-intensity interval training (HIIT) on LV dimensions and survival in HF patients.
  • To assess the relationship between changes in VO2peak, LV geometry, and mortality risk in HF.

Main Methods:

  • A matched-control cohort study involving 202 HF patients (2009-2016).
  • Comparison between a multidisciplinary disease management program (MDP) group (n=101) and a HIIT group (n=101) completing 36 sessions.
  • Assessment of VO2peak and LV geometry during an 8-year follow-up; determination of 5-year all-cause mortality.

Main Results:

  • HIIT group showed a 14-20% increase in VO2peak; each 1-mL/kg/min VO2peak increase correlated with a 58% improvement in 5-year mortality.
  • Increased LV end-systolic diameter (LVESD) was significantly associated with higher mortality (p=0.0198).
  • HIIT participants demonstrated significantly improved 8-month survival (p=0.044) compared to the non-exercise group.
  • HF patients with VO2peak ≥14.0 mL/kg/min and LVESD <44 mm had a superior 5-year survival rate (98.2%) versus those with poorer metrics (57.3%).

Conclusions:

  • HIIT is associated with improved VO2peak and favorable LV geometry changes in HF patients.
  • Both increased VO2peak and decreased LVESD induced by HIIT are linked to enhanced survival rates in heart failure.
  • HIIT represents a valuable therapeutic strategy for improving long-term outcomes in heart failure management.

Keywords:
cardiac rehabilitationcumulative survival rateheart failureoxygen consumptionventricular remodeling

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